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L929 were co-cultured with the leachate of each group for 24 h, then digested and centrifuged with 0.25% trypsin, and the supernatant was discarded and added to the complete medium, and the concentration of the cells was adjusted to 4 10 5 /ml

Finally, the nuclei were stained with DAPI (C1002, Beyotime) and the images were obtained using High-Definition Rapid Three-dimensional Imaging

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