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SORD deficiency affects mitochondrial morphology and network architecture Mitochondrial dysfunction is a common feature across multiple CMT2 subtypes 17,18,33 , and data from Drosophila indicated that also SORD mutation can lead to mitochondrial dysfunction 15

It represents an iron-driven lipid peroxidation-mediated RCD which has recently drawn wide attention in cancer research due to its contribution to tumorigenesis as well as in relation to the opportunity to target it pharmaceutically as a cancer treatment strategy [159, 160]

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However, additional ROS induces harmful effects on plant cells