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2.2 Transcriptional regulatory networks 2.2.1 Epigenetic dominance of the TOX/NR4A family In the fate determination of exhausted T cells, the transcription factors of the TOX and NR4A families serve as masterminds, reshaping the gene expression profile of T cells through epigenetic regulation, gradually plunging them into the quagmire of exhaustion (112, 113)

Iron overload alters the number and viability of T-lymphocyte subpopulations and the distribution of lymphocytes in different compartments of the immune system ( C-myc and Mdn2 gene expression ( In relation to the treatment of RA, it has been found that the iron ion chelator desferrioxamine (DFO) has been used to prevent synovial damage and improve RA anemia ( 2.2 Lipid peroxidation in RA Lipid peroxidation is central to ferroptosis

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doi: 10.1016/j.neuroimage.2024.120632, 22 HupfeldK