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A 2008 study published in the Journal of Medicinal Chemistry demonstrated metabolic effects in rodent models at 50mg/kg, which led early researchers to extrapolate human-equivalent doses between 50100mg daily

Folic acid is used to treat anemia caused by low red blood cell count and may decrease the risk of heart disease by lowering blood homocysteine levels

This occurs when the bone marrow suddenly starts producing platelets more effectively, along with a rebound effect where platelet production overshoots normal levels