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However, in states of activation, including oncogenesis, B cell activation depends on G6PD and PPP activity to mitigate oxidative stress ( 4 The effect of G6PD in other cell types important for immunity Beyond leukocytes, it is relevant to consider other cell types that contribute to innate immune activation and systemic inflammatory responses, including red blood cells, platelets, hepatocytes, and endothelial cells

10.1210/jc.2007-1747 J

Endocr Rev 31:364395 Tripathy BC, Oelmller R (2012) Reactive oxygen species generation and signaling in plants

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