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Die langfristigen Auswirkungen der selektiven Elimination seneszenter Zellen beim Menschen sind noch nicht vollstndig verstanden

10.1007/s40263-025-01226-z 60 HongC

doi: 10.1016/0304-3940(93)90134-7 263 CooperAJPlumF

For instance, abnormalities in mitochondrial energy metabolism, impaired lysosomal degradation, and activation of the endoplasmic reticulum unfolded protein response not only promote abnormal Syn aggregation but also exacerbate oxidative stress and neuroinflammation, creating a vicious cycle