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and (2) mitochondrial dysfunction, leading to neuroinflammation, impaired neuroprotection, and age-related disease progression (Jiang and Cadenas, 2014

AFMU = 5-acetyl-amino-6-formylamino-3-methyluracil

10.1074/jbc.M300931200 128 MehtaP.RaymondJ.ZhangY.PunjaniR.HanM.LarsonT.et al (2023)

For example, ZnT2 is strikingly overexpressed in luminal cells (T47D, poorly invasive) and luminal tumors, which could protect cells from zinc cytotoxicity by mobilizing zinc into intracellular vesicles 60