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Consistently, in relapsed AML/MDS after allo-HCT, high frequencies of CTLA-4/PD-1 and multi-ICMco-expressing T cells and blasts are detectable in uncultured blood and associate with impaired antileukemic activity and poor response to salvage therapy (54)

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Compared to age-matched controls, PD patients exhibited significantly elevated levels of proinflammatory cytokines such as IL-1B, IL-6, and TNF in CSF and blood (58)

and (c) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(b), wherein said polynucleotide does not hybridize under stringent conditions to a nucleic acid molecule having a nucleotide sequence of only A residues or of only T residues