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They are low-molecular-weight polyphenolic molecules, mainly consisting of two benzene rings (A and B) bonded together by three carbons and an oxygen atom to form a pyran (C) (Figure 6)

As expected, after M1EV-assisted targeted delivery of HMPB-HKN 15 to tumor tissues, the release of endogenous iron triggered by the photothermal effect further amplified ferroptosis, which combined with antitumor immunity exerted the strongest tumor-killing effect

Because it works at the most fundamental level of energy production, MOTS-c is often a starting point in a comprehensive peptide therapy protocol, creating a solid foundation upon which other therapies can build

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