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Additionally, although we have established a connection between the anti-acne effects of LP-EVs and their enriched proteins through proteomic analysis and proteinase inhibition assays, future investigations should employ targeted approaches, such as generating mutant bacteria lacking key proteins, exogenously expressing specific candidate proteins, and using small molecule inhibitors to precisely link individual proteins to downstream signaling pathways in the host identified by transcriptomic analysis above and their acne-related biological effects

Choice B: Fluoroquinolones are broad-spectrum antibiotics that inhibit bacterial DNA topoisomerase and are often used for complicated respiratory, genitourinary, and gastrointestinal infections

Angew Chem Int Ed 48:11981229 Seo YH, Carroll KS (2009) Facile synthesis and biological evaluation of a cell-permeable probe to detect redox-regulated proteins

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