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Studies and Research In a Japanese trial, 3 of 6 carcinoma patients had either tumor regression or stagnation of tumor growth after glutathione therapy

This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012

doi: 10.1038/s41467-020-17064-0 8 DaiSMLiFJLongHZZhouZWLuoHYXuSGet al

(iv) the ENS and vagus nerve connecting to (v) central autonomic circuits and HPA stress pathways