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Al bloquear el sitio activo de la enzima de forma permeable a membrana, 5-Amino-1MQ reduce la produccin de 1-MNA y preserva la nicotinamida disponible, lo que en modelos experimentales se asocia con restauracin de los niveles intracelulares de NAD+ y SAM

Fischer A, Han W, Hu S, Husl MM, Wannemacher J, Kadri S, et al

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For genotyping, DNA from toe clipping of littermate animals was extracted using a house-made Lysis buffer (0.1 M Tris-HCl pH 7.5, 0.1 M EDTA, 0.1 M NaCl, 1% SDS), and the PCR was performed using primers described in Supplementary Dataset 5 and the products were analyzed on an agarose gel