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The study population had a mean age of 54 years and a mean BMI of 36.1 kg/m 2 and experienced a BW reduction of 12.8%, 14.7% and 3.2% with tirzepatide 10 mg, tirzepatide 15 mg and placebo, respectively, at 72 weeks 37

Very small individuals (under 50kg) might start at the lower end of dose ranges

An experimental study observed that SIRT1 activators improve insulin sensitivity and muscle endurance by increasing mitochondrial biogenesis (Nishida et al