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Even though it seems that the technology has been researched extensively, many factors still remain inconclusive

Patients should be reviewed 812 weeks after commencing treatment to assess: Symptomatic improvement, particularly resolution of fatigue and neurological symptoms Haematological response (normalisation of haemoglobin and mean cell volume) Reticulocyte count typically rises within one week, indicating bone marrow response Repeat serum B12 testing is generally not useful after starting parenteral therapy, as levels remain elevated for months

CONCLUSION Acute severe ulcerative colitis as defined by Truelove Witts criteria is a medical emergency that requires immediate hospitalization

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