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Zhang L, Xiu L, Wang T, Zhao D

Preclinical Studies Early preclinical studies in rodent obesity models demonstrated that AOD9604 administration reduced body weight and fat mass without affecting food intake, indicating a direct metabolic effect rather than an appetite-suppressing mechanism

In an abstract to the Endocrine Societys 95th Annual Meeting and Expo in 2013, administration of ALRN-5281 demonstrated an increase of growth hormone in rats (administered intravenously) and dogs (administered twice weekly subcutaneously)

Concomitant use of metformin and proton pump inhibitors increases risk of vitamin B12 deficiency