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Recent studies have highlighted an overactivation of this pathway in several human cancers [104]

Analogous to the CNS, it integrates sensory neurons, interneurons, and motor neurons to form autonomous sensory-motor reflex arcs, which are the essential framework for the autonomous regulation of digestive tract functions (Niesler et al., 2021)

Synergistic effects of the two tropomyosin inhibitors TR100 or AMT-3507 have been observed in combination with the anti-microtubule drug vincristine, which also targets the cytoskeleton [122]

Moreover, given its multi-component, multi-pathway, multi-target, multi-efficacy nature and low side effects, traditional Chinese medicine (TCM) has been used to manage similar fundus lesions since at least 620 CE (Cao et al., 2022)