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Second generation mTOR inhibitors as a double-edged sword in malignant glioma treatment

Myo-Ins slightly, but significantly, increased the ionomycin response amplitude (~ 20%) and, in contrast to the histamine response, also increased the AUC (~ 28%), indicating an increase of the total releasable intracellular Ca pool

NAC may be useful when: Cysteine availability may be limiting The goal is to support internal glutathione synthesis Direct glutathione is poorly tolerated A clinician has identified a relevant medical or nutritional reason NAC does not guarantee that glutathione production will increase adequately