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One of the possible roles of vir genes is that they could be exhibiting cytoadherence with host cell receptors as in reported studies, The single vir gene documented to have shown binding in the reported study, (PVX-108770, vir_C,) has shown 50% and above upregulation in the patient samples with hepatic dysfunction in our data

Verkade MA, van Druningen CJ, Vaessen LM, Hesselink DA, Weimar W, Betjes MG, et al

West PR, Amaral DG, Bais P, Smith AM, Egnash LA, Ross ME, Palmer JA, Fontaine BR, Conard KR, Corbett BA, Cezar GG, Donley ELR, Burrier RE

Change history 27 September 2021 A Correction to this paper has been published: Abbreviations AE: Adverse event KD: Ketogenic diet MeSH: Medical subject headings MD: Mitochondrial disease MAD: Modified Atkins diet OXPHOS: Oxidative phosphorylation PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses PDHC: Pyruvate Dehydrogenase Complex References Thompson K, Collier JJ, Glasgow RIC, Robertson FM, Pyle A, Blakely EL, et al