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Description

Screening with the P4 1 2 1 2 system Crystals in the P4 1 2 1 2 space group were grown as described above

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- 6

The ligand occupies the ATP binding site of c-Met, competes with ATP by forming hydrogen bonds with Met 1160, and binds with Asp 1222 in the active region of c-Met to form hydrogen bonds, thus producing strong kinase inhibitory activity (Fig