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p53 inhibits ferroptosis by reducing the accumulation of toxic lipid ROS and inducing the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21) (Figure 1) (Li and Li, 2020

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The IV works by reducing melanin production, detoxifying the body, and boosting collagen production, which results in brighter, clearer, and more even-toned skin

26 In vivo, the combination of ibrutinib and RSL3 was superior to either monotherapy alone, both of which significantly delayed disease progression, further supporting our previous observations (Fig