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While saline is certainly not a harmful substance, and theres no proof an IV drip is a performance enhancer, WADA restricted the practice because athletesmost prominently Lance Armstronghave used saline drips in order to increase their blood plasma volume and thereby mask the use of drugs

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Moreover, both itaconate-cysteine and sulfoitaconate were found to increase dramatically by LPS stimulation in iBMDM cells, which were even more profound than the elevation of itaconate (Supplementary Fig