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During testing, each mouse was placed in an acoustically trans-parent, unrestrained acrylic cage (9.8 5 5.5 cm) within an anechoic chamber (startle reflex chamber, XR-XZ208, Xinruan, Shanghai, China)

In landmark longevity and metabolic clinical trials, researchers often utilize very high, weight-based dosagesapproximately 100 mg of NAC and 100 mg of glycine per kilogram of body weight per day

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Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate