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Thus, targeting OXPHOS alone or in combination with other metabolic pathways could be an attractive therapeutic strategy to re-sensitise LSCs and AML blasts to conventional chemotherapeutic agents and improve AML patient outcomes

Further, IGF-I was described to regulate the expression of miR-143, leading to an increase in IGFR expression in PC-3 and DU145 prostate cancer cell lines

Once patients began experiencing moderate-to-severe neuropathic symptoms, alpha-lipoic acid was introduced

In observational studies, data demonstrated that patients treated with NSAIDs in the post-MI period were at increased risk of reinfarction, CV-related death, and all-cause mortality