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Aberrations in EV biogenesis, alterations in their cargo composition (e.g., dysregulated miRNA profiles), or dysfunctional intercellular signaling can transform these vital molecular messengers into drivers of pathology

The metal binding proteins facilitate the absorption of Zn and metal ions by procuring the binding sites

The modified metabolites generated by phase I enzymes will further be modified by phase II conjugation enzymes, which are mostly transferase enzymes that can transfer the endogenous hydrophilic molecules to the metabolite to increase the solubility and promote excretion

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