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Supplementation of butyrate (all Sigma-Aldrich, Germany) was done in the drinking water at a final concentration of 150 mM and changed every 3 days and control mice received pH and sodium-matched water

JHU-083 markedly suppresses the recruitment of MDSCs by decreasing tumor-derived CSF3 levels via degradation of C/EBP, which in turn increases the numbers of proinflammatory TAMs and enhances antigen presentation to CD8(+) T cells, resulting in stronger T-cell responses 150

IGF-I may be beneficial in the mild types of motor neuron diseases since IGF-I is a pro-survival factor for motor neuron-derived cells[79]

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