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Gluud LL, Dam G, Les I, et al

Nakata T, Creasey EA, Kadoki M, et al

In summary, CAV2 knockdown led to mitochondrial dysfunction by disrupting mitochondrial structure or function, destabilizing electron transport chain complexes, resulting in reduced electron transport efficiency, decreased ROS and MMP, impaired ATP synthesis, and lower proton leak

For example, the surveyed incidence of self-reported ethanol-induced flushing reactions in Scandinavians living in Copenhagen as well as Australians of European descent is about 16% in individuals homozygous for the "normal" ADH1B gene but runs to ~23% in individuals with the ADH1-Arg48His SNP variant