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With meals: L-carnitine can be taken with a meal to aid in its absorption

10.1371/journal.pone.0052493 12

One part of glucose is transformed into pyruvate by a pyruvate kinase (PK), providing the first net gain of ATP, while the other part of PEP can be transformed into oxaloacetate by a phosphoenolpyruvate carboxylase (PEPC) or phosphoenolpyruvate carboxykinase (PEPCK), which provides the second net ATP gain