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Lipid peroxidation increases ROS generation and damages cell membranes, activating a series of pro-apoptotic signaling molecules (e.g., caspase-3, p53), which lead to muscle cell apoptosis

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For example, metabolic pathways associated with energy production like pentose phosphate pathway, glycolysis, Kerbs cycle, electron transport chain (ETC) of mitochondria, biosynthesis of adenosine triphosphates (ATPs), synthesis of energy-generating amino acids such as lysine and methionine, and photorespiration linked amino acids such as arginine, serine, glutamic acid and glycine were reported to be upregulated

To do so, we identified viral sequences from publicly available metagenomic datasets from drinking water distribution systems from around the world to assess viral taxonomic diversity and metabolic potential