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Tears cause pain with gripping, twisting, and weight-bearing through the wrist

Axitinib (AG-013736)

Int J Rheum Dis 24:254259

In ALS, reduced astrocytic EAAT2 levels and altered microRNA regulation (e.g., increased miR-218 and decreased miR-124a) result in the accumulation of EAAT2-derived toxic species, accumulation of glutamate, and motor neuron degeneration