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An example of such amino acid substitution is the replacement of N297 by a glycine or an alanine

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HYP can successfully reach the brain through the BBB, and the metabolic process is rapid, reaching a peak value about 0.5 h after entering the brain, and the basic metabolism is complete within 3 h (100) (see Table 6 )

Inflammatory bowel diseases, which include ulcerative colitis and Crohns disease, are chronic diseases with an incompletely understood etiology [95, 96]