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860 Nutrition studies have found a U-shaped association between iron intake and OA progression in the knee joint, with appropriate iron intake helping to prevent OA progression, while excess or insufficient iron intake increases the risk of OA progression

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Furthermore, immunohistochemical staining of neuronal activity in spinal cord dorsal horn neurons reveals a dramatic increase in c-Fos-positive neurons (activated neurons) after 4 weeks of methylmercury exposure and a decrease in the number of activated neurons after 14 weeks of exposure