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Therefore, investigating the mechanisms of action of various drugs and devising strategies to prevent drug resistance will be imperative to achieve more precise and effective targeting of breast cancer cells

Abbreviations ADL: Activities of daily living ANOVA: Analysis of variance BMI: Body mass index (kg/m 2 , kilograms per meter squared) BML: Bone marrow lesion BMAC: Bone marrow aspirate concentrate DEGs: Differentially expressed genes EKOA: Early-stage knee osteoarthritis HTO: High tibial osteotomy IQR: Interquartile range KOOS: Knee injury and osteoarthritis outcome score MOAKS: Magnetic resonance imaging osteoarthritis knee score MSCs: Mesenchymal stem cells MRI: Magnetic resonance imaging OA: Osteoarthritis OA-BMLs: Osteoarthritis-associated bone marrow lesions OARSI: Osteoarthritis research society international PRP: Platelet-rich plasma QOL: Quality of life SD: Standard deviation SRA: Sport and recreation activities TKA: Total knee arthroplasty TKR: Total knee replacement UKA: Unicompartmental knee arthroplasty VAS: Visual analog scale WOMAC: Western ontario and mcmaster universities osteoarthritis index References Moradi K, Kubassova O, Carrino JA

developed a Noto -cre mouse model to target node and posterior notochord formation during gastrulation (McCann et al., 2012)