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Since its identification in the 1990s by the research group of Sikiric et al., it has become one of the most extensively studied peptides in tissue repair research, with published data spanning tendon healing, angiogenesis, nitric oxide regulation, and gastrointestinal cytoprotection

On day 6, cells were counted, and 100 l cell suspension (in DMEM media supplemented with only 10% FBS but no antibiotics) was added to the 96-well plates (containing siRNA and transfection mix) at the appropriate seeding density (12k for DMSO and 15k for etoposide-treated cells)