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doi: 10.1038/s41388-018-0506-7

For translational applications, sustained intranasal delivery aligns far closer with canonical, long-term longevity phenotypes Source: Open Access Paper: Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs Institution: University of Washington, Seattle, WA Country: USA Journal: bioRxiv (Preprint) Impact Evaluation: The impact score of this journal is 0 (as a preprint server without a formal Clarivate index)

The final solution was lyophilized to obtain GSH-CDs-Ce6

Glutathionylation activates both p21ras, leading to phosphorylation of ERK and Akt as downstream targets, and ryanodine receptors, causing calcium signals that enhance ERK and CREB phosphorylation