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PHD activates the pseudohypoxic response by stabilizing HIF-1, which is a well-known tumorigenesis enhancer, and as a transcription factor, maintains the metabolic reprogramming of cancer cells to support their survival 127

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In this role it is not free-floating at all

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10.4161/bioe.26003 Bioengineered 40 DavisG

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In high light stress, however, high light energy can inhibit PSII, resulting in a reduction in electron transfer efficiency

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