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baumannii in Beas 2B cells and inhibit the activation of the NLRP3 inflammasome by decreasing the generation of ROS and mtROS and lowering the release of inflammatory cytokines (IL-18 and IL-1) through the upregulation of SIRT1 ( Figure 3b )

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IGF/IGF-1R is activated by basic FGFs (bFGF) to maintain MSC multipotency, and disruption of the IGF-1R pathway with specific molecular inhibitors reduces OCT4/NANOG/SOX2 expression (Park et al., 2009)