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The role of oxidative stress in recurrent pregnancy loss (RPL) is an understudied and enthralling field of investigation

GSH is synthesized in two steps, both ATP-dependent processes, catalyzed by the enzymes GCL (glutamate-cysteine ligase, aka -glutamylcysteine synthetase) and glutathione synthetase, and is regenerated by six enzyme-catalyzed reactions, known as the -glutamyl cycle