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Diabetic nephropathy, another major complication, involves progressive kidney damage that can lead to proteinuria, decreased glomerular filtration rate (GFR), and eventually end-stage renal disease [182]

D., Eertmans, F., & Schoonjans, F

A 2014 study in the Journal of Clinical Investigation confirmed kisspeptin as the mediator of sex steroid negative feedback to the hypothalamus in women

Allowing these ACOs more flexibility would have the effect of supporting continued Shared Savings Program participation among these ACOs, including those serving rural and underserved populations