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J Pept Sci 9:471501 Davitt K, Babcock BD, Fenelus M, Poon CK, Sarkar A, Trivigno V, Zolkind PA, Matthew SM, Grinkina N et al (2014) The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells

Thus, based also on preclinical data, specific targeting of TNFR1 or TNFR2 by antibodies, small molecules or aptamers may represent a safer and more effective treatment in IMIDs in the future [196,197,198]

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