is glutathione produced in the michocondria Depletion Mitochondrial Diseases Glutathione (GSH) and antioxidant enzymes,

Due to the similar substrate specificity and presence of a cysteine as a catalytic residue, M pro is classified as a 3C-like protease 82

Finally, while COX1 and COX2 metabolize AA into the inflammatory eicosanoids PGE2 and PGI2, acetylsalicylic acid (ASA) inhibits COX1 and modifies COX2 by acetylation (ASA-COX), leading to a shift from production of the precursor of PG, to 15-R-HpETE which is converted by the 5LO to AT-LXA4 (15-epi-LXA4) (Birnbaum et al., 2007) ( Figure 3 )

Pollock S, Taylor S, Oyerinde O, et al.: The dark side of skin lightening: an international collaboration and review of a public health issue affecting dermatology

John Myers