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Description

EdU staining Cells subjected to genetic treatments were seeded into 12-well plates at a density of 5 10 cells per well and cultured for 24 hours

To reduce variance caused by the sex difference, the male animals were chosen for experiments [14]

Abbreviations: SD, standard deviation

Engagement of PD-1 by its ligands results in the recruitment of protein tyrosine phosphatases such as Src homology region 2 domain-containing phosphatase-2 (SHP2), which antagonizes downstream pathways required for metabolic reprogramming of activated T cells, including PI3K/Akt, Ras, ERK, Vav, and phospholipase C gamma (PLC) [106]