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First-degree relatives of vitiligo patients have a 68% risk of developing the disease, and the concordance rate between monozygotic twins is approximately 23%.28,34 Five genome-wide association studies (GWAS) have been conducted on vitiligo in European and Asian populations, identifying at least 54 vitiligo susceptibility loci.49,50 Human leukocyte antigen region Several genes within the human leukocyte antigen (HLA) region, specifically in class I and II regions, are associated with vitiligo