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Shimizu M, Ohta K, Yang Y, Nakai A, Toma T, Saikawa Y, et al

doi: 10.1111/j.1749-6632.1990.tb00140.x 44 TaylorEW

Glaucomatous optic neuropathy: mitochondrial dynamics, dysfunction and protection in retinal ganglion cells

H 2 O 2 reacts with ferrous iron (Fe 2+ ) in the Fenton reaction generating the highly toxic hydroxyl radical (OH) which can damage all cellular macromolecules (Imlay, 2003, 2008)