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2020 Oct;35:100835

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We have taken advantage of the ease with which ligand complexes can be produced in GR crystals, a property that extends to the isomorphous GRTR crystals, and have produced and analyzed crystals of GRTR complexes with glutathione, trypanothione, glutathionylspermidine and of a true catalytic intermediate, the mixed disulfide between trypanothione and the enzyme

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As the material may need to be administered more than once a day, and for a prolonged period of time, the use of injections using needles becomes even less attractive

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