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Huwait et al., 2022

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These mice also exhibited exercise impairment (Wilson et al., 2009).Notably, the circulating aldosterone levels (6.5 ng/ml) in this model (Tanaka et al., 2014) appear to be within the same order of magnitude as human patients with acute HF (18 ng/ml) ( 2.1.3 Deoxycorticosterone acetate (DOCA)-salt administration (H 2 FPEF score 2) This model was originally developed in 1969 to study hypertension in rats (Willard, 1969) and involves administration of DOCA for 4 weeks by intraperitoneal injection or subcutaneous implant, followed by unilateral nephrectomy and salt loading with 1% NaCl in drinking water

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