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Later, beginning at about 6 hours after ketamine administration, there is an increased expression of genes associated with new synapses, including genes expressed by axon terminals, such as synapsin 1 and SV2A, and genes that are expressed by the postsynaptic dendritic spine, such as PSD95 and GluR1, said Krystal

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Tang Q, Lu B, He J, Chen X, Fu Q, Han H, et al

However, while ROS-driven signalling has been studied as a pathological factor, ROS as a signalling molecule is as essential as ATP production (Palma et al, 2024)