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However, as in the case of LC, in these other post-infectious subgroups of ME/CFS, EBV could also play a possible role in immunological alterations and symptomatology, since the virus is present in 90% of the population [170] and therefore could be reactivated in the presence of immunosuppression [128130, 133140]

Abbreviations AD: Alzheimer's disease CDCrel-1: Cell division control-related protein 1 DA neuron: Dopaminergic neuron ETC: Electron transport chain GWAS: Genome-wide association study HTRA2: High-temperature requirement protein A2 IBR: In-between-ring LRRK2: Leucine-rich repeat kinase 2 mtDNA: Mitochondrial DNA NdufA10: NADH dehydrogenase ubiquinone 1 sub-complex 10 NESC: Neuroepithelial stem cells NFB: Nuclear factor B Nrf2/ARE: The nuclear factor erythroid 2-related factor 2/antioxidant receptor element PD: Parkinson's disease PINK1: Phosphatase and tensin homolog-induced kinase 1 ROS: Reactive oxygen species SN: Substantia nigra SNCA: Alpha-synuclein TFAM: Mitochondrial transcription factor A TRAP1: Tumor necrosis factor receptor-associated protein 1 Ubl: Ubiquitin-like UPS: Ubiquitinproteasome system UQ: Ubiquitin VPS35: Vascular protein sorting-associated protein 35 References Abdelkader NF, Safar MM, Salem HA (2016) Ursodeoxycholic acid ameliorates apoptotic cascade in the rotenone model of parkinsons disease: modulation of mitochondrial perturbations

Interestingly PUMA interacts with HER2 and is phosphorylated at Y152 and Y172 this phosphorylation increased degradation of the protein and reduces apoptosis induction ( BAX/BAK BAX and BAK form pores in the outer mitochondrial membrane and drive mitochondrial permeabilization (Wei et al., 2001

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke