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However, due to variations in initial litter size, the average litter weight gain did not differ among the four treatment groups

GST catalyzes the conjugation of reactive metabolites, such as phosphoramide mustard, into less toxic compounds like 4-glutathionyl-cyclophosphamide ( GST genes variants associated with occurrence of adverse effects-related to CYC are GSTM1 , GSTP1 and GSTT1 ( GSTA1 is not included in this discussion, as its polymorphisms have been reported to influence the efficacy of CYC treatment rather than its toxicity or adverse effects ( GSTM1 gene encodes Glutathione S-transferase Mu 1 (GSTM1), a key phase II detoxification enzyme that catalyzes the conjugation of glutathione to electrophilic compounds, including toxic metabolites of cyclophosphamide such as acrolein and phosphoramide mustard ( GSTM1 null genotype is the common polymorphism in GSTM1

Astroglial atrophy in Alzheimer's disease

Notably, the sensitivity of tumor cells and CTLs to ferroptosis in the TME remains controversial