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Description

A study to assess the efficacy of enasidenib and risk-adapted addition of azacitidine in newly diagnosed IDH2-mutant AML

A practical consideration specific to this stacks dosing research is the asymmetric reconstitution planning the two compounds require

Diagnosis is by recognising the typical oral pattern, gastroenterology workup including colonoscopy and biopsy, blood tests (FBC, CRP, faecal calprotectin) and sometimes biopsy of an oral lesion (showing non-caseating granulomas)

Human peripheral blood mononuclear cells (PBMC) from G6PD-d patients harboring G6PD variants have demonstrated reduced IL-10 secretion in response to stimulation 49,50,51