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Selection of appropriate non-clinical animal models to ensure translatability of novel AAV-gene therapies to the clinic

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Annexin A5 ameliorates traumatic brain injury-induced neuroinflammation and neuronal ferroptosis by modulating the NF-kB/HMGB1 and Nrf2/HO-1 pathways

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2.2 Experimental design Sixty rats approximately 3 weeks old at the start of the treatment, were randomly assigned into six groups, with 10 rats in each group

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Lifestyle interventionsincluding weight management, smoking cessation, antiinflammatory diets, and regular lowimpact activitysupport longterm spine health and often prevent the need for surgery

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